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All India Institute of Medical Sciences, Nagpur

 
  • Designation: Assistant Professor
  • Qualification: PhD (Biochemistry)
  • Email: ashwinbutle@aiimsnagpur.edu.in 
        Areas of expertise
  • Research and Teaching

 
Membership 

  • Society of Biological Chemists (India), Life Membership No. 3021, 2013.

Training

  • Training program on ‘Transgenic Animal Technology: Basics and Methods’, from Ministry of Human Resource Development Govt. of India, in School of Life Sciences, University of Hyderabad.
  • Training for ‘Molecular Biology & Cloning’ and ‘Protein Expression, Purification and Analysis’. GeNext Genomics Pvt. Ltd. Nagpur.
  • Interdisciplinary training on ‘Research Methodologies’, Dr. Ambedkar Institute of Management Studies and Research, Nagpur
  • Training on ‘Statistical Methods’ by RTM Nagpur University in Department of Statistics, Hislop Collage, Nagpur.
  • Workshop on ‘Patents and Related Issues’, by Technology Park, Patent Cell, Nagpur
  • Workshop cum Training program on ‘Rattus Species: In Research and Education’, by Continuing Technical Skill Development Program, Department of Biochemistry, RTM Nagpur University, Nagpur
  • Workshop cum Training program on ‘Bioinformatics’ in collaboration of Sai Bioinfosys and Department of Biochemistry, RTM Nagpur University, Nagpur

Publications

  • Butle AB, Talmale SA, Jadhao VV, Patil MB, Lambat TL. Immunostimulatory and anti-allergic potential of novel heterotrimeric lectin from seeds of Zizyphus mauritiana Lam. Int J Biol Macromol. 2021;171:389-97. IF: 8.02
  • Butle A, Joshi A, Noronha V, Prabhash K, Dutt A. Weekly osimertinib dosing prevents EGFR mutant tumor cells destined to home mouse lungs. Transl Oncol. 2021;14(8):101111. IF: 4.80
  • Butle A#, Joshi A#, Hait S, Mishra R, Trivedi V, Thorat R, et al. Osimertinib for lung cancer cells harboring low-frequency EGFR T790M mutation. Transl Oncol. 2022;22:101461. (# : Co-first authors), IF: 4.80
  • Dharavath B, Butle A, Pal A, Desai S, Upadhyay P, Rane A, et al. Role of miR-944/MMP10/AXL- axis in lymph node metastasis in tongue cancer. Nature, Commun Biol. 2023;6(1):57. IF: 6.54
  • Dharavath B, Butle A, Chaudhary A, Pal A, Desai S, Chowdhury A, Singh R, Thorat R, Upadhyay P, Nair S,  Dutt A. The UBEC3-LRP5 Fusion is a Novel Oncogenic Driver in Head and Neck Cancer with Therapeutic Implications" Reference number: NPJPRECISIONONCOLOGY-03640 (accepted in Nature, Precision Oncology, Feb 20,2024  IF: 10.09)

Honours and Awards : 

  • National Post Doctoral Fellowship, SERB-Department of Science and Technology, Govt of India
  • Scientific Officer (Ad-hoc), bestowed by Director ACTREC, Tata Memorial Center, Navi Mumbai
  • Institutional Post Doctoral Fellowship, ACTREC, Tata Memorial Center, Navi Mumbai
  • First Rank (Abstract presentation): Isolation of Immunomodulatory Protein from the Seeds of Zizyphus mauritiana. National Conference on Recent Trends in Life Science Material Sciences and Home Sciences, 04 Oct 2015, at Hotel Center point, by SMV Nagpur.
  • Second Rank (Abstract presentation): Isolation of a Thermostable Protein with Antibacterial and Antifungal Activity from Wild Plant. UGC Sponsored State Seminar on, Exploration of Biochemistry & Molecular Biology for Betterment of Human Life, at Pulgaon, India. 29 Jan 2014.

Miscellaneous :

Abstract Published:

  • Ashwin Butle, Asim Joshi, Vanita Noronha, Kumar Prabhash, and Amit Dutt. Weekly osimertinib dosing to prevent EGFR mutant tumor cells destined to home mouse lungs. Journal of Clinical Oncology 2021 39:15_suppl, e20504; American Society of Clinical Oncology (IF: 50.79) https://ascopubs.org/doi/10.1200/JCO.2021.39.15_suppl.e20504

Other Publications:

  • Bharat Rekhi#, Vinayak Dave#, Ashwin Butle#, Bhasker Dharavath, Sonali Khetle, Archana Kumari Redhu, Rudransh Singh, Amit Dutt, Immunohistochemical expression of H3.3G34W in 100 giant cell tumors of bone and its diagnostic mimics, including its value in resolving uncommon diagnostic scenarios: A single Institutional study at a tertiary cancer referral centre, India. . Indian J Pathol Microbiol. 2024 Feb 12. doi: 10.4103/ijpm.ijpm_886_23. Epub ahead of print. PMID: 38391356.
  • Trivedi V, Noronha V, Sreekanthreddy P, Desai S, Poojary D, Varughese L, Gowda P, Butle A, et al., (2023) Association of Cutibacterium acnes with human thyroid cancer. Endocrinol. 14:1152514. doi: 10.3389/fendo.2023.1152514 IF: 6.05
  • Rekhi B, Dave V, Butle A, Dutt A. Utility of immunohistochemical expression of H3.3K36M and DOG1 in the diagnosis of chondroblastomas: An experience from a tertiary cancer referral center. Ann Diagn Pathol. 2023 Oct;66:152174. doi: 10.1016/j.anndiagpath.2023.152174. Epub 2023 Jun 21. PMID: 37356274. IF: 2.13
  • Desai S, Dharavath B, Manavalan S, Rane A, Redhu AK, Sunder R, Butle A, et al Fusobacterium nucleatum is associated with inflammation and poor survival in early-stage HPV-negative tongue cancer. NAR Cancer. 2022;4(1):zcac006. IF: 5.1
  • Lambat T, Deo S, Butle A. Plasma marker based hepatoprotective evaluation of some novel synthesized benzofluorenone analogues: A medicinal chemistry approach, Karbala Int J Mod Sci. 2017 1;3: 39 – 45. ISSN 2405-609X; https://doi.org/10.1016/j.kijoms.2017.02.002. IF: 1.53.

Abstracts/ Posters Presentations:

  • 5th Masterclass in Lung Cancer, Aegis of Cancer Research & Statistic Foundation-Mumbai, Institute of Pulmonology Medical Research & Development. Oral Presentation Topic: Weekly Osimertinib In Lung Cancer – Pre-Clinical Data. at Hotel Courtyard by Marriott, Mumbai.
  • 4th Annual conference of Indian Association of Cancer Research (IACR), Oral Presentation Topic: Characterization of therapeutically relevant genomic alterations in cervical cancer using orthotopic cervical cancer mouse model. Amity University, UP, Noida.
  • 8th National conference of The Indian Society Of Medical and Pediatric Oncology (ISMPOCON), Oral presentation in Translational Science, Oral Presentation Topic: Preclinical orthotopic xenograft cervical cancer mouse model for characterization of genomic alterations and novel therapeutics.
  • Annual Conference of Oncology Forum (OFCON), Oral Presentation Topic: An orthotopic mice model for lung cancer closely recapitulates clinical disease in NOD-SCID mice to study TKI resistance. Virtual Platform Conference.
  • National Conference on Recent Trends in Chemical Engineering and Technology (REACT-2015), Oral Presentation Topic: Immobilization of Industrially Important B-Galactosidase Isolated from Wild Plant. Laxminarayan Institute of Technology (LIT), Nagpur.
  • Third Global Sustainable Biotech Congress, by Global Biotech Forum, Nagpur & CETYS University, Mexico, Oral Presentation Topic: In vitro study on glutathione metabolism in T-lymphocytes during HAART therapy of HIV/AIDS- potential antioxidative effect of lectin from seeds of Zizyphus mauritiana’. North-Maharashtra University, Jalgaon.