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All India Institute of Medical Sciences, Nagpur

General Medi Research and Publications

Ongoing Projects:



Title of the Project

Name of faculty

Ongoing/ Completed/In pipeline



A Randomized Double-Blind, Two arm, Placebo controlled Clinical Trial to Evaluate the Efficacy and Safety of Mycobacterium w in preventing COVID-19 in subjects at risk of getting infection with COVID-19, Clinical Study Protocol No.: CRSC20005


A Randomozed, Double-blind, Two arm, controlled clinical trial to compare the Efficacy and Safety of Mycobacterium w (Mw) administered along with Standard of care versus Placebo administered along with Standard of care, in adult, COVID19 positive patients hospitalized but not critically ill, Clinical study protocol No.; CRSC20006

 Dr. P.P.

Joshi (PI)

Dr Amol Dube (Co-PI)

Dr Bharat Rathod (Co-PI)



Clinical profile and outcomes in  COVID 19 suspect/confirmed cases patients

Dr. P. P. Joshi (PI)



INDIGENIUS  study (CVD-02-CD-002)

 A randomized open label 2- Treatment Group Clinical trial evaluating the efficacy and safety of 2-Deoxy-D-Glucose as an adjunctive therapy to standard of care in comparison to standard of care in acute treatment of moderate to severe Covid-19 patients.

Dr. S. Kumbhalkar (PI)



Efficacy and safety of Ivermectin as an add on therapy to standard in Covid 19- A pilot study 

Dr. P. P. Joshi (PI)

Dr. A. H.Dube



A Randomized open label study to evaluate the efficacy and safety of Favipiravir and Umifenovir as compared to Favipiravir alone in moderate adult Indian Covid-19 patients

Dr. R. S. Khot (PI)



Study of serum vitamin D level and its correlation with severity of illness and outcome in COVID-19.

Dr. B. D. Rathod (PI)



A Multi-Centre, Prospective, Open Label, Parallel, Randomized, Clinical Trial to Assess the Efficacy And Safety Of Molnupiravir 800 Mg Capsules And Standard of Care (SoC) Compared To Standard of Care (SoC) Only In Mild Patients With Polymerase Chain Reaction (PCR) Confirmed COVID-19 

Dr. R. S. Khot (PI)



JIP-MC-KFAJ: A Randomized, Double-Blind, Placebo-Controlled, Phase 2 Study of LY3471851 (NKTR-358) in Systemic Lupus Erythematosus

Dr. R. S. Khot (PI)



Post Covid symptoms and recovery times in hospitalized Adult Covid 19 patients.

Dr. R.S. Khot (PI)



A randomized, double-blind, placebo-controlled,

multicenter study of ensovibep (MP0420) in ambulatory

adult patients with symptomatic COVID-19:

The “EMPATHY” Trial

Dr. P. P. Joshi

Dr Amol Dube



A Randomized, Double-blind, parallel Arm, Multicenter Study to Evaluate the Efficacy and Safety of Nitric Oxide Nasal Spray Combined with Standard Supportive Care in Adult non- Hospitalized Patients with COVID-19

Dr. S. Kumbhalkar

Dr. Bharat Rathod

On Going


A Phase III, Prospective, Randomized, Open Label, Active Controlled, Parallel Group, Multicenter Clinical Study to Evaluate the Efficacy, Safety and Tolerability of a Fixed Dose Combination of Vildagliptin and Dapagliflozin Tablets 50mg/5mg of USV Private Limited, India as compared to Concomitant Administration of Reference product, Galvus 50mg tablets (Vidagliptin) of Novartis Pharmaceuticals UK Ltd., along with Forxiga 5mg tablets (Dapagliflozin) of AstraZeneca Pharmaceuticals, USA in patients with type 2 Diabetes Mellitus Inadequately Controlled in earlier metformin containing dual therapy

Dr. Amol Dube

Dr. Prashant P. Joshi

Dr. Ganesh Dakhale

Dr. Udit Narang

On Going


A phase 3, multicentre, randomized double blind doubledummy, parallel-group active control to compare the efficacy and safety of a fix dose combination of Metformin Hydroclhoride 1000mg ER, Sitagliptin phosphate 100mg and Dapaglifozin propanediol 10mg tablets VS Janumet XRC, combipack of Metformin hydrochloride 1000mg SR and Sitagliptin phosphate 100mg in patients with Type 2 diabetes mellitus (T2DM)

Dr. Sunita Kumbhalkar

Dr. Keshao Nagpure

On Going




  • Riya M Waghale, Rajashree Sanjay Khot, Prashant P Joshi. Platelet volume indices: markers of carotid atherosclerosis in type 2 diabetes mellitus?  Clinical Diabetology May 2020; 9(2): 103–111.
  • Bidkar V, Mishra M, Selvarajan K, Joshi P,Shrikrishna BH, Rathod BD. Testing Olfactory and Gustatory Dysfunctions among Quarantine COVID-19 Suspects. Indian J. Otolaryngol Head Neck Surg. Oct 2020. https;//doi/10.1007/s12070-020-02210-3
  • RajashreeKhot, Bhawana Sonawane. Brittle bones, deformities and Deafness. Indian J Med Res, 2020 (November),152 (Suppl);120 DOI: 10.4103/  ijmr.IJMR_2196_ 19.
  • Bishakha J. Rathi, RajashreeKhot, Prashant P. Joshi. Eating Disorders and their Clinical corelates in Diabetes Mellitus. IJMSCR, 2020;3(6): 325-334.


  • Harshal Pise, Rajashree Khot, PP Joshi. Monoclonal Antibodies in Covid 19- Where do we stand? Vid J of Int Med, 2021;Vol 30: 58-65.
  • Khot R, Dube AH, Rathod BD, Joshi PP, Kumbhalkar SD. Impact of lockdown period on chronic diseases. Indian J Med Spec 2021; Volume 12; Issue 3: 22-27
  • Rathod BD, Nagar VS, Kaushik A. Incidence, Risk Factors, Clinical Profile And Outcome Of Invasive Candidiasis Intensive Care Unit Of Tertiary Care Hospital. International Journal of Medical Science and Applied Research (IJMSAR). Vol.4, issue-1, Jan-Feb-2021, Page :30-37
  • Thakker V, Bhangare S, Joshi R, Ghotkar V, Chavhan P, Thomare G, Joshi PP. Prevalence of cardiovascular risk factors, their awareness and gender differences in Adolescents, Indian Journal of Applied Research  2021; Volume – 11; Issue – 05: 1-5 (Print ISSN no. 2249-555X/DOI:10.36106/ijar).
  • Khot R, Kumbhalkar SD, Juneja R, Joshi PP. The Development of Ecchymosis after Administration of Convalescent Serum in a Patient with COVID-19 Associated with Thrombocytosis. Eur J Case Rep Intern Med. 2021 Sep 13;8(9):002782. doi: 10.12890/2021_002782. PMID: 34671574; PMCID: PMC8523374.
  • Juneja R, Kamal F, Gadkari R, Kumbhalkar S, Borkar S. An Undiagnosed Case of Jaundice: Who Is the Culprit, Liver Or RBC- An Interesting Case Report of HbH Disease. IJMSCR. 2021 July-August; 4 (4):120-23.


  • Borkar SR, Khot R, Joshi PP, Kamal F. A study of post COVID syndrome in patients admitted in a Hospital in central India. GJRA. 2022;1 (02):1-2.
  • Rathod BD, Amle D, Khot RS, Prathipati KK, Joshi PP. Neutrophil-to-Lymphocyte Ratio as a Predictor of Disease Severity and Mortality in Coronavirus Disease 2019: Prospective Study From Central India. Cureus. 2022 Mar 31;14(3):e23696. doi: 10.7759/cureus.23696. PMID: 35519791; PMCID: PMC9064266.
  • Prathipati KK, Mishra M, Rathod B, Tripathy JP, B H S, Bidkar V, Dabhekar S, Shete V, Gadwal D. Symptomatology and Relationship Between Symptoms and Duration Among COVID-19 Patients in a COVID-19 Care Hospital in Central India. Cureus. 2022 Jan 24;14(1):e21541. doi: 10.7759/cureus.21541. PMID: 35223314; PMCID: PMC8865598.
  • Dabhekar S, Basagoudanavar S, Bidkar V, Prathipati K, Sujiv A, Rathod BS, Gadwal D. A Study of Symptomatology of COVID-19 Laboratory-Confirmed Cases at Tertiary Care Center: A Cross-Sectional Study. Cureus. 2022 Feb 13;14(2):e22186. doi: 10.7759/cureus.22186. PMID: 35308685; PMCID: PMC8925989.
  • Ahirwar AK, Takhelmayum R, Sakarde A, Rathod BD, Jha PK, Kumawat R, Gopal N. The study of serum hsCRP, ferritin, IL-6 and plasma D-dimer in COVID-19: a retrospective study. Horm Mol Biol Clin Investig. 2022 Mar 31. doi: 10.1515/hmbci-2021-0088. Epub ahead of print. PMID: 35357792.
  • Medhi Rupjyoti, Swapnil Akhade, Keshao B. Nagpure, and Krishnadutt Chavali. “Lead Toxicity Following a Novel Method of Consumption as a Tea Preparation Using Vermillion for Arthralgia: A Case Report.” Asia Pacific Journal of Medical Toxicology 10, no. 4 (December 1, 2021): 151–53.
  • Davile Medha, Nagpure Keshao . “Knowledge, Attitude and Practice (KAP) Assessment Towards COVID- 19 Outbreak Among Pregnant Women at a Tertiary Care Hospital in Central India: A Cross Sectional Study” Indian Journal of Obstetrics and Gynecology , Volume 9 Number 3, July–September 2021: 13-18
  • Gaikwad, Ujjwala Nitin, Oshrika Bose, Abhishek Padhi, Atul Jindal, Keshao Nagpure, Anudita Bhargava, and Padma Das. “A Retrospective Observational Insight into COVID-19 Exposures Resulting from Personal Protective Equipment (PPE) Breaches.” PLOS ONE 17, no. 5 (May 17, 2022): e0268582.
  • Deepa M, Elangovan N, Venkatesan U, Das HK, Jampa L, Adhikari P, Joshi PP, Budnah RO, et al for the ICMR– INDIAB Collaborative Study Group. Evaluation of Madras Diabetes Research Foundation (MDRF)-Indian Diabetes Risk Score (IDRS) in detecting undiagnosed diabetes in the Indian population: Results from the ICMR–INDIAB population-based study (INDIAB–15). Indian Journal of Medical Research. 2022.
  • Bidkar, V., Shrikrishna, B.H., Dabhekar, S. et al. Tracing, Tracking and Treating COVID-19 Associated Rhino-Orbito Cerebral Mucormycosis (ROCM). Indian J Otolaryngol Head Neck Surg (2022).
  • Rathod BD, Ahirwar AK, BanerjeeS, Joshi PP, Khot RS, Dube AH etal. Association of Vitamin D with severity of disease and mortality in COVID-19: Prospective study in central India. Ann Afr Med 2022. (Accepted for Publication).
  • Pitale S, Sahasrabuddhe A, Gandhi P, Joshi P, Sakhare A, Balankhe N  et al. Clinical and Demographic Profile of Diabetic Patients from Central India - Results and Diabetes Registry. Accepted for Publication in Indian Journal of Endocrinology and Metabolism on 27th August 2022.
  • John J, Amle D, Takhelmayum, Gopal N, Mishra M, Joshi P, Rathod B, Gadkari R. Association of COVID 19 RT PCR cycle threshold value with surrogate marker of disease severity.(Accepted for Publication in Cureus)


Chapters Published by faculty:

  • Dr. P. P Joshi:  Wrote a Chapter on “Trypanosomiasis” in API Text Book of Medicine, 12th Edition. (Association of Physicians of India (API) Text Book in Medicine, is popular, standard, widely read and recommended Textbook in General Medicine for Undergraduate, Postgraduate students and  practicing physicians all over the country).(Page Number e-66-e70)
  • Dr. P. P. Joshi: Wrote a Chapter on “Clinical features of COVID-19” in COVID Document
  • Dr. Udit Narang: API Textbook of Medicine, 12th Edition: Chapter No 15. Miscellaneous: Including Household and Other Poisoning (Page No: 2120 – 2126)
  • Dr. Udit Narang: Effects in Comorbidities and Special Population, 1st Edition: Chapter No 12: COVID in Geriatric Population (Page No:343-355)