JavaScript Required We're sorry, but this site doesn't work properly without JavaScript enabled. If you can't enable JavaScript please click here to view settings.

All India Institute of Medical Sciences, Nagpur

 
  • Designation: Associate Professor
  • Qualification: MBBS, MD (Biochemistry), DNB (Biochemistry)
  • Email: dnyanesh@aiimsnagpur.edu.in
         Areas of expertise
  • Clinical Biochemistry,
  • Molecular Biology,
  • Biomarkers in Diabetes Mellitus, cancer, sickle cell disease and renal diseases

Membership 

  • Association of Medical Biochemists of India,
  • Association of clinical chemistry and laboratory medical practitioners
  • Society of cancer research
  • National Medical Organisation

Training

  • Clinical biochemistry analysers
  • Electro chemiluminiscence
  • ELISA
  • DNA EXTRACTION
  • PCR
  • RFLP
  • SDS PAGE
  • Flow cytometry
  • Confocal Microscopy
  • Gel electrophoresis
  • Automated electrophoresis
  • Chromatography
  • Bioinformatics essentials

Publications

  • Amle DB, Koner BC. Use of red vacutainer for collection of CSF causes falsely high estimation of proteins by pyrogallol red method. Clinica ChimicaActa 444 (2015) 62–65
  • Amle DB, Khaneja A, AgarwalS, Ahlawat R, Ray PC, Mir R, Saxena A. Association of 18 bp Insertion/Deletion Polymorphism, At -2549  position of VEGF Gene, with Diabetic Nephropathy in Type 2   Diabetes Mellitus patients of North Indian Population.  Journal Of diabetes and Metabolic Disorders,2015;14:19
  • Mir R, Bhat M, Javaid J, Shah N, Kumar P, Sharma E, Amle D et al. Glutathione S-transferase M1 and T1 (rs4025935 and rs71748309) null genotypes are associated with increased susceptibility to coronary artery disease in Indian populations. Acta Cardiologica. 2016;71(6):678-684.
  • Amle DB, Patnayak RL, Verma V, Singh GK, Jain V, Khodiar PK, Patra PK. VEGF Promoter Region 18-bp Insertion-Deletion Polymorphism in Sickle Cell Disease Patients with Microalbuminuria: A Pilot Study. Indian Journal of Hematology and Blood Transfusion. 2018:1-6.
  • Das J, Chandra L, Gandhi G, Amle DB, Patnayak RL, Khurana N, Saxena A. Evaluation of promoter hypermethylation of tumor suppressor gene BRCA1 in epithelial ovarian cancer. Journal of Cancer Research and Therapeutics. 2022 Oct 1;18(6):1578-82.

Books / Chapters

  • Cell Cycle, In Review of Molecular Biology
  • Tripathi SC, Fahrmann J, Amle D. Targeting the Immuno-Oncology Metabolism in Cancer. InImmuno-Oncology Crosstalk and Metabolism 2022 May 17 (pp. 117-152). Singapore: Springer Nature Singapore.

Miscellaneous

Honors and Awards:

  • Best poster award in AMBICME 2013, Dnyanesh Amle, Alka Khaneja , Sarita Aggarwal, Ravinder Ahlawat, Rashid Mir, P C Ray, Alpna Saxena, Serum VEGF and VEGF gene polymorphism in patients with Diabetic Nephropathy : A therapeutic perspective.
  • 1st Prize in AMBICON National PG Quiz 2013.
  • 1st Prize AMBI (Delhi Chapter)-scientific meeting quiz, March 2014.
  • Best Poster Award 4th AMBICON CG-State Chapter, Rajanandgaon.
  • Best Poster Award 2nd Prize AMBICON 2017 (International Conference), Dr. Dnyanesh Amle1, Dr. Gajendra Singh1, Dr. Swati Hiwale1, Dr. Onkar Khandwal2, Dr. P. K. Khodiar2, Dr. P. K. Patra3. Urinary Gamma Glutamyl transfarase to creatinine ratio is early diagnostic markers for Sickle cell disease associated nephropathy
  • 1st Prize Paper Presentation, 5th AMBI-CG state chapter, Durg February 2018
  • 1st Prize Paper presentation, GAPIO-2020 , Nagpur (Travel fellowship to UK) (Co-author)
  • 3 Guest lectures in national Symposia and conferences
  • Guest Faculty for 4 National Workshops (Genetics and Molecular biology, Confocal Microscopy)
  • Organizing secretary National symposium on "Genetic Basis of Haematological disorders with Special emphasis on Sickle Cell Disease" on25th and 26th July 2016 which will be followed by a seven days "Hands-on-Workshop' on "Molecular Diagnostics".  
  • Organizing secretary: Ubiquizone: Vidarbha level Undergraduate quiz for Biochemistry: 15th February 2020.

Reviewer to:

  • Turkish Journal of Hematology
  • BAOJ Chemistry
  • Enzymology and Metabolism Journal
  • Karger group of journals

Presentations:

  •  Platform presentations: 24 (8 First author+16 Co-author)
  •  Poster presentations: 19 (7 First author +12 Co-author)
  •  3 Guest lectures in national Symposia and conferences
  •  Guest Faculty for 4 National Workshops (Genetics and Molecular biology, Confocal Microscopy)

Recent Publications:

  • Jain D, Netam SBS, Patre V, Amle D, Sahu R, Gahine R. Role of Diffusion-weighted Imaging, Perfusion Magnetic Resonance Imaging, and Magnetic Resonance Spectroscopy in Evaluating Histopathologically Confirmed Brain Tumors in 3-Tesla Magnetic Resonance Imaging. Int J Sci Stud 2019;7(2):24-37.
  • Jain R, Prashant V, Amle D. Post Operative Evaluation of Coagulation Profile as a Prognostic Marker in Patients Operated for Perforation Peritonitis', International Journal of Current Advanced Research 2019; 08(04), 18095-98.
  • Rao BN, Rathia SK, Phuljhele S, Verma YK, Amle D. Incidence, risk factors, clinical profile, and determinants (affecting outcome) of new onset acute kidney injury developing in critically Ill patients in pediatric intensive care unit of a tertiary hospital in middle India. Int J Pediatr Res. 2019;6(05):252-261
  • Bardhan M, Tiwari R, Amle D et.al. Assessment of Cormic Index insickle cell disease subjects and its association with clinical severity. International Journal of Science & Healthcare Research. 2019; 4(4): 70-78.
  • Devangan V, Phuljhele S, Amle D, Patra P. K. Iron profile parameters status in sickle cell disease patients: a case control study from Chhattisgarh India. Indian Journal Of Applied Research. June 2020. 10;5:1-3
  • Jhuma Das, Lal Chandra, Evaluation Of Promoter Hypermethylation Of Tumour Suppressor Gene BRCA1 In Epithelial Ovarian Cancer, Journal of cancer research  and therapeutics, accepted in Journal of cancer research and therapeutics
  • Shivnani, D., Raman, E.V. & Amle, D. The COVID TIDE Approach: A Protocol for Safe Tracheostomy Practice in COVID Patients. Indian J Otolaryngol Head Neck Surg (2021). https://doi.org/10.1007/s12070-021-02370-w

List of research projects

As chief investigator

  • Efficiency of crossover group teaching method to learn Renal function test in first year MBBS students and difficulties encountered
  • Assessment of fluorometric properties of Haemoglobin in subjects with COVID-19
  • Implementation of Jigsaw tutorial as a technique of peer learning: an experience in first year MBBS students.
  • Association of Thyroid autoimmunity with female factor infertility in economically under-privileged population visiting AIIMS, Nagpur- a case control study.

As Co- investigator

  • Urinary enzymes as early diagnostic marker for cisplatin induced renal damage: a comparison with Cystatin C
  • Urinary enzymes as early diagnostic marker for diabetic nephropathy: a comparison with Cystatin C.
  • Comparative efficacy of various anticoagulants in COVID-19 subjects: an observational study
  • Awareness of hypertension and demographic factors Influencing hypertension treatment among rural population of Krishna district.
  • Laryngomalacia- when to intervene? Decision Making for Management of Laryngomalacia
  • The study of biochemical parameters and viral load in COVID-19 patients with and without complications: A cross-sectional study
  • Impact of Post-COVID neuropsychiatric and cognitive manifestations on functioning and quality of life and their association with biomarkers of COVID illness severity and neuronal damage.
  • Potential impact of TNF-α  rs1800629 G>A, IL-10 rs1800896 A>C, IL8rs4073 T>A, CXCR2 rs2230054 C>T gene abnormalities with susceptibility to SARS-CoV-2, hypertension , coronary artery disease and COVID-19 disease mortality

List of presentation in the conference

  • Poster titled “Study of 18bp Insertion/Deletion Polymorphism in Vascular Endothelial Growth Factor Gene in cervical cancer metastasis” at 8th Annual conference of Association of Clinical Chemistry and Lab Medicine Practitioners in on 08/01/2022 at Guwahati Assam
  • Delivered invited guest lecture in Workshop on HPLC at “28th National Annual Conference of Association of Medical Biochemists of India” at Raipur Chhattisgarh on 02/12/21
  • Delivered invited guest lecture on POCT: changing paradigms in laboratory medicine and challenges in “ 8th Annual conference of Association of Clinical Chemistry and Lab Medicine Practitioners” on 08/01/2022 at Guwahati Assam.
  • Poster titled “Study of 18bp Insertion/Deletion Polymorphism in Vascular Endothelial Growth Factor Gene in cervical cancer metastasis” at “8th Annual conference of Association of Clinical Chemistry and Lab Medicine Practitioners” on 08/01/2022 at Guwahati Assam

Awards

  • Best poster award for Poster titled “Study of 18bp Insertion/Deletion Polymorphism in Vascular Endothelial Growth Factor Gene in cervical cancer metastasis” at 8th Annual conference of Association of Clinical Chemistry and Lab Medicine Practitioners in on 08/01/2022 at Guwahati Assam
  • Best poster award for Poster titled “Study of 18bp Insertion/Deletion Polymorphism in Vascular Endothelial Growth Factor Gene in cervical cancer metastasis” at “8th Annual conference of Association of Clinical Chemistry and Lab Medicine Practitioners” on 08/01/2022 at Guwahati Assam

Events

  • Hosted UbiQuizone, undergraduate quiz for 1st year MBBS students in Biochemistry, in February 2020, at AIIMS, Nagpur
  • Part of the scientific committee for Hybrid national CME on “Translational medicine – from bench to the bedside “ held at AIIMS Nagpur on 28th July 2022
  • Part of the scientific committee for workshop on “Cell culture techniques” held at AIIMS Nagpur on 29th July 2022