 |
|
Areas of expertise
- Proteomics
- Metabolomics
- Early diagnosis
- Biomarkers
- Therapeutic intervention
- Drug resistance
- Cancer biology
- Cancer immunolog
|
Membership & Training
-
American Association for Cancer Research (AACR)
-
Indian Association of Cancer Research (IACR)
-
International Association for the Study of Lung Cancer (IASLC)
- American Society of Clinical Oncology (ASCO)
-
Indian Society for Atherosclerosis Research (ISAR)
Publications
- Prasad CP, Tripathi SC, Kumar M, Mohapatra P. Passage number of cancer cell lines: Importance, intricacies, and way-forward. Biotechnol Bioeng. 2023 Aug;120(8):2049-2055. doi: 10.1002/bit.28496. Epub 2023 Jul 13. PMID: 37439093
|
- Pajai S, John JE and Tripathi SC. Targeting immune-onco-metabolism for precision cancer therapy. Front. Oncol. 2023 Feb; 13:1124715. doi: 10.3389/fonc.2023.1124715
|
- Sreekumar S, Kuthe AM, Tripathi SC, Patil GC, Ravikumar C. Integrated Computational Approach towards Identification of HSPG and ACE2 Mimicking Moieties for SARS-CoV-2 Inhibition. J Mol Liq. 2022 Dec 1;367:120566. doi: 10.1016/j.molliq.2022.120566. PMID: 36276265 PMCID: PMC9578758.
|
- Li YJ, Fahrmann JF, Aftabizadeh M, Zhao Q, Tripathi SC, Zhang C, Yuan Y, Ann D, Hanash S, Yu H. Fatty acid oxidation protects cancer cells from apoptosis by increasing mitochondrial membrane lipids. Cell Rep. 2022 May 31;39(9):110870. doi: 10.1016/j.celrep.2022.110870. PMID: 35649368.
|
|
Books / Chapters
- . Tripathi SC, Jose J, Takhelmayum R (2020). “Biology of Some Specialized Cells: Cancer”. Cytology: An Introduction and Analysis. Koshal Publications. Jan 2020
-
Tripathi, S.C., Fahrmann, J., Amle, D. (2022). Targeting the Immuno-Oncology Metabolism in Cancer. In: Macha, M.A., Bhat, A.A., Wani, N.A. (eds) Immuno-Oncology Crosstalk and Metabolism. 2022 May 17; pp 117–152; Springer, Singapore. https://doi.org/10.1007/978-981-16-6226-3_5
- Biomarkers for early detection of Cancer: A proteomic approach”. Biomarkers in Cancer: Discovery, Technologies, and Applications. Springer Nature publications
Miscellaneous:-
Honors And Awards:
- Scholar in Training Award in AACR-IASLC International Joint Conference on “Lung Cancer Translational Science from the Bench to the Clinic” held on 4th-7th January 2016, San Diego, California, USA.
- Scholar in Training Award in AACR-NCI-EORTC International Conference on “Molecular Targets and Cancer Therapeutics” held on 12th-16th November 2011, San Francisco, California, USA
- Scholar in Training Award in AACR International Conference on “The Future of Molecular Epidemiology: New Tools, Biomarkers, and Opportunities” held on 6th-9th June 2010, Miami, Florida, USA.
- Scholar in Training Award in Eighth Annual AACR International Conference on “Frontiers in Cancer Prevention Research” held on 6th-9th Dec 2009 at Houston, Texas, USA.
- Young Investigator Travel Award in HUPO2009 World congress on “Proteomics of Human Health: Environment and Diseases” held on 26th-30th Sep 2009 at Toronto, Canada.
- Travel Grant from Department of Science and Technology, Govt. of India for attending HUPO2009 World congress on “Proteomics of Human Health: Environment and Diseases” held on 26th-30th Sep 2009 at Toronto, Canada.
- Travel Grant from Indian National Science Academy for attending HUPO2009 World congress on “Proteomics of Human Health: Environment and Diseases” held on 26th-30th Sep 2009 at Toronto, Canada.
- Senior Research Fellowship from Indian Council of Medical Research, Government of India- from February 2009-2011.
- Student Fellowship awarded by AIR INDIA Pvt. Ltd- from July 1995-2006
Presentations:
- SC Tripathi, JF Fahrmann, M Celiktas, M Aguilar, KD Marini, MK Jolly, H Katayama, H Wang, EN Murage, JB Dennison, DN Watkins, H Levine, EJ Ostrin, A Taguchi, SM Hanash. MCAM modulates small cell lung cancer chemoresistance via PI3k/Akt/Sox2 signaling pathway. 108th Annual Meeting of the American Association for Cancer Research; 2016 Apr 1-5; Washington, D.C., USA.
- M Çeliktaş, I Tanaka, SC Tripathi, JF Fahrmann, CA Bonavides, P Villalobos, O Delgado, DS Dhillon, J Dennison, EJ Ostrin, H Wang, C Behrens, KA Do, A Gazdar, SM Hanash, A Taguchi. CPS1 as a therapeutic target and prognostic indicator in LKB1-inactivated lung adenocarcinoma. 108th Annual Meeting of the American Association for Cancer Research; 2016 Apr 1-5; Washington, D.C., USA.
- MK Jolly, D Jia, SC Tripathi, S Mooney, M Celiktas, SM Hanash, SA Mani, KJ Pienta, EB Jacob, H Levine. Stability and stemness of the hybrid epithelial-mesenchymal phenotype. 108th Annual Meeting of the American Association for Cancer Research; 2016 Apr 1-5; Washington, D.C., USA.
- C Kerros, SC Tripathi, D Zha, S Anna, HL Peters, H Katayama, P Sukhumalchandra, KR Cox, AA Perakis, LS St John, G Alatrash, EA Mittendorf, KC Dwyer, SM Hanash, JJ Molldrem. Neuropilin-1 mediates neutrophil elastase uptake and antigen cross-presentation in breast cancer cells. 108th Annual Meeting of the American Association for Cancer Research; 2016 Apr 1-5; Washington, D.C., USA.
- RM Mbofung, JA McKenzie, S Malu, C Liu, L Williams, W Peng, Z Wang, SC Tripathi, T Tieu, S Zhao, S Devi, I Kuiatse, E Ashkin, L Bailey, J Roszik, S Hanash, T Heffernan, RE Davis, RN Amaria, P Hwu. Inhibition of HSP90 enhances T cell-mediated antitumor immune responses through expression of interferon-alpha response Genes. 107th Annual Meeting of the American Association for Cancer Research; 2016 Apr 16-20; New Orleans, LA, USA
- M Lu, M Capello, SC Tripathi, H Levine, EB Jacob, SM Hanash, J Onuchic. The role of exosome-mediated cell-cell communication in inducing phenotypic changes. 107th Annual Meeting of the American Association for Cancer Research; 2016 Apr 16-20; New Orleans, LA, USA.
- SC Tripathi, HL Peters, EJ Ostrin, A Taguchi, H Katayama, H Wang, A Momin, MK Jolly, M Celiktas, J Rodriguez, C Behrens, II Wistuba, EB Jacob, H Levine, JJ Molldrem, SM Hanash. Loss of immunoproteasome driven by EMT is associated with immune evasion and poor prognosis in non-small cell lung cancer. Fourth AACR-IASLC International Joint Conference: Lung Cancer Translational Science from the Bench to the Clinic. January 4-7, 2016: San Diego, CA, USA.
- SC Tripathi, HL Peters, EJ Ostrin, A Taguchi, H Katayama, H Wang, A Momin, MK Jolly, M Celiktas, J Rodriguez, C Behrens, II Wistuba, EB Jacob, H Levine, JJ Molldrem, SM Hanash. Immunoproteasome deficiency is a feature of NSCLC with a mesenchymal phenotype and is associated with restricted antigen presentation and poor outcome in patients. CRI-CIMT-EATI-AACR - The Inaugural International Cancer Immunotherapy Conference: Translating Science into Survival. September 16-19, 2015: New York, NY, USA.
- SC Tripathi, HL Peters, EJ Ostrin, A Taguchi, H Katayama, H Wang, A Momin, MK Jolly, M Celiktas, J Rodriguez, C Behrens, II Wistuba, EB Jacob, H Levine, JJ Molldrem, SM Hanash. Immunoproteasome deficiency is associated with poor prognosis in early stage non-small cell lung carcinoma. Translational Molecular Pathology Retreat. June 11-12, 2015: Houston, TX, USA.
- SC Tripathi, HL Peters, EJ Ostrin, A Taguchi, H Katayama, H Wang, A Momin, MK Jolly, M Celiktas, J Rodriguez, C Behrens, II Wistuba, EB Jacob, H Levine, JJ Molldrem, SM Hanash. Immunoproteasome deficiency is associated with poor prognosis in early stage non-small cell lung carcinoma. Canary Foundation Early Detection Symposium. May 5, 2015: Stanford, CA, USA.
- C Kerros, SC Tripathi, AV Philips, G Al-Atrash, KE Ruisaard, KC Dwyer, EA Mittendorf, SM Hanash, JJ Molldrem. Characterization of Neutrophil elastase uptake in breast cancer: implications for immunotherapy. AACR Annual Meeting. April 18-22, 2015: Philadelphia, PA, USA.
- HL Peters, SC Tripathi, H Katayama, C Kerros, A Perakis, LS St. John, G Al-Atrash, SM Hanash, Jeffrey J. Molldrem. Neutrophil elastase induces post-transcriptional increase of surface MHC class I expression on lung cancer cells. AACR Annual Meeting. April 18-22, 2015: Philadelphia, PA, USA.
- HL Peters, SC Tripathi, G Al-Atrash, EA Mittendorf, SM Hanash, JJ Molldrem. Serine Proteases Neutrophil Elastase and Proteinase 3 Alter the Antigen Repertoire of the MDA-MB-231 Breast Cancer Cell Line. Texas Cancer Vaccine Symposium. Jan 13, 2015: Houston, TX, USA.
- Polo like kinase 1 inhibition potentiates radiation effect in GBM cells. 39th Annual Conference of Indian Association of Cancer research (IACR-2020). Thiruvananthapuram, Kerala, India. 02/2020
- Immunoproteasomes: a different strategy to treat lung cancer. Department of Stem Cell Transplantation & Cellular Therapy: Seminar Series. Houston, TX, USA 09/2014
Editorial And Review Activities
Editor/Service on Editorial Board(s)
- Interventions in Gynecology and Women’s Healthcare
- Frontiers in Molecular Biosciences
- International Journal of Clinical Oncology and Cancer Research
Journal Reviewer
- PLOS One
- Journal of Cellular Physiology
- Medicine
- Anti-Cancer Agents in Medicinal Chemistry
Total number of publications: 37
Recent Publications:
- Tripathi SC, Jolly MK, Mani SA, Levine H. Editorial: Characterizing the Multi-Faceted Dynamics of Tumor Cell Plasticity. Front Mol Biosci. 2021 Jan 20;7:630276. doi: 10.3389/fmolb.2020.630276. eCollection 2020.
- Tripathi SC, Deshmukh V, Creighton CJ, Patil A. Renal Carcinoma Is Associated With Increased Risk of Coronavirus Infections. Front Mol Biosci. 2020 Nov 20;7:579422. doi: 10.3389/fmolb.2020.579422. eCollection 2020.
- Subbalakshmi AR, Kundnani D, Biswas K, Ghosh A, Hanash SM, Jolly MK,Tripathi SC. NFATc Acts as a Non-Canonical Phenotypic Stability Factor for a Hybrid Epithelial/Mesenchymal Phenotype. Front Oncol. 2020 Sep 8;10:553342. doi: 10.3389/fonc.2020.553342. eCollection 2020.
- Patil A, Tripathy JP, Deshmukh V, Sontakke B, Tripathi SC. SeXX and COVID-19: tussle between the two. Monaldi Arch Chest Dis. 2020 Sep 18;90(4). doi:10.4081/monaldi.2020.1461.
- Tripathi SC, Deshmukh V, Patil A, Tripathy JP. COVID 19 diagnostic multiplicity and its role in community surveillance and control. Infez Med 2020 Jun 1;28(suppl 1):18-28.
- Deshmukh V, Tripathi SC, Pandey A, Deshmukh V, Vykoukal J, Patil A, Sontakke B. COVID-19: A Conundrum to Decipher. Eur Rev Med Pharmacol Sci 2020; 24 (10): 5830-5841
- Fahrmann JF, Vykoukal J, Fleury A, Tripathi S, Dennison JB, Murage E, Wang P, Yu CY, Capello M, Creighton CJ, Do KA, Long JP, Irajizad E, Peterson C, Katayama H, Disis ML, Arun B , Hanash S. Association between plasma diacetylspermine and tumor spermine synthase with outcome in triple negative breast cancer. J Natl Cancer Inst. 2019 Sep 10. doi: 10.1093/jnci/djz182. [Epub ahead of print]
- Bocci F, Tripathi SC, Vilchez Mercedes SA, George JT, Casabar JP, Wong PK, Hanash SM, Levine H, Onuchic JN, Jolly MK. NRF2 activates a partial epithelial-mesenchymal transition and is maximally present in a hybrid epithelial/mesenchymal phenotype. Integr Biol (Camb). 2019 Jun 1;11(6):251-263. doi: 10.1093/intbio/zyz021.
- Tripathi SC, Fahrmann JF, Vykoukal J, Dennison JB, Hanash S. Targeting metabolic vulnerabilities of cancer: Small molecule inhibitors in clinic. Cancer Rep 2019 Feb;2(1):e1131. doi: 10.1002/cnr2.1131. Epub 2018 Sep 23.
- Capello M, Vykoukal JV, Katayama H, Bantis LE, Wang H, Kundnani DL, Aguilar-Bonavides C, Aguilar M, Tripathi SC, Dhillon DS, Momin AA, Peters H, Katz MH, Alvarez H, Bernard V, Ferri-Borgogno S, Brand R, Adler DG, Firpo MA, Mulvihill SJ, Molldrem JJ, Feng Z, Taguchi A, Maitra A, Hanash SM. Exosomes harbor B cell targets in pancreatic adenocarcinoma and exert decoy function against complement-mediated cytotoxicity. Nat Commun. 2019 Jan 16;10(1):254. doi: 10.1038/s41467-018-08109-6.
Research projects
Special lectures
- The Immunoproteasome: a smoking gun in cancer immunotherapy at AIIMS Delhi
Awards
- Dr Awtar Krishan Award in Quiz competition at ‘23rd Indo-US Flowcytometry workshop’ held at Rajasthan on 10/03 2022
Events
- Organising secretary for Hybrid national CME on “Translational medicine – from bench to the bedside “ held at AIIMS Nagpur on 28th July 2022.
- Organising secretary for workshop on “Cell culture techniques” held at AIIMS Nagpur on 29th July 2022.